Author(s): C. Contarino; E. F. Toro; A. Louveau; S. Da Mesquita; D. Raper; I. Smirnov; J. Kipnis; N. Agarwal

Linked Author(s):

Keywords: Mathematical model; Murine fluid systems; Idiopathic intracranial hypertension; Cerebrospinal fluid; Meningeal lymphatics

Abstract: Building upon the recent discovery of a meningeal lymphatics system for the mouse and mathematical modelling capabilities developed for extracellular fluids in humans, here we propose a holistic, multi-scale and closed-loop mathematical model for the murine circulatory system coupled to the cerebrospinal fluid (CSF), and the CSF-draining lymphatic system. A validation of the mathematical model for the circulatory system is provided by comparing the theoretical model results with in-vivo pressure and MRI flow measurements. The mathematical model shows how the intracranial venous and CSF fluid compartments respond to the high pressure arterial cerebral blood inflow, in particular, by displacing CSF into the spinal subarachnoid space. We will show how the dynamics of the cerebral fluid is influenced by impairments of the venous system through the computational model and measurements on a mouse model of Idiopathic Intracranial Hypertension, a neurological disorder characterized by an abnormal intracranial pressure increase. Preliminary theoretical results show that under ligation of the major intracranial-blood draining vessels, the intracranial pressure increases by more than 100%, and this is broadly in agreement with experimental measurements.

DOI: https://doi.org/10.3850/978-981-11-2731-1_373-cd

Year: 2018